How we turned a transfection problem into a platform

Vectorialis began inside genT_LAB at Politecnico di Milano, where the founding team had spent years on a stubborn problem in non-viral gene delivery: nucleic acid complexes that assemble passively in solution are heterogeneous, and that heterogeneity is what drives the variability researchers see at the bench

Turning that insight into a platform meant developing the vibrational hardware and the reagent chemistry together, since neither worked without the other. Over three years, the hardware parameters and the polymer formulation were refined against each round of bench data, and the result was VibroFect®

The VibroFect® patent family covers both the method and the reagents. Vectorialis S.r.l. was incorporated in 2026 as a spin-out of Politecnico di Milano by Gabriele Candiani and Nina Bono, to bring VibroFect® out of a single academic lab and into transfection workflows worldwide

Today fifteen research groups across academia and industry use the platform, for pDNA, mRNA, and siRNA delivery into primary and hard-to-transfect cells. The company is run by the same group that developed the technology